tadalafil tadalista 40 mg is the strongest dosage available for treating erectile dysfunction. The medication works by promoting blood flow to the penis and encouraging an erection. It also treats pulmonary hypertension by relaxing the muscles in blood vessels of the lungs to allow blood to flow more easily. The dosage of this medicine is determined by your doctor and depends on several factors, including your medical history and current medications. You should discuss any medications you are taking with your doctor before you begin taking this drug, as it can interact with them. You should also avoid consuming grapefruit juice or eating alcoholic beverages while you are taking this medicine.